Assay Detail
Functional
CHEMBL3744103
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Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New substituted 9-propyladenine derivatives as A2Aadenosine receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.62 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506450 | — | — | 1 | 6.70 |
| CHEMBL3087706 | — | — | 1 | 6.60 |
| CHEMBL3739795 | — | — | 1 | 5.83 |
| CHEMBL475023 | — | — | 1 | 5.77 |
| CHEMBL3740631 | — | — | 1 | 5.76 |
| CHEMBL3741012 | — | — | 1 | 5.75 |
| CHEMBL3739903 | — | — | 1 | 5.75 |
| CHEMBL3742158 | — | — | 1 | 5.73 |
| CHEMBL3740141 | — | — | 1 | 5.69 |
| CHEMBL3740619 | — | — | 1 | 5.50 |
| CHEMBL3741217 | — | — | 1 | 5.34 |
| CHEMBL3739922 | — | — | 1 | 5.20 |
| CHEMBL3741167 | — | — | 1 | 5.13 |
| CHEMBL3740992 | — | — | 1 | 5.08 |
| CHEMBL3739985 | — | — | 1 | 5.03 |
| CHEMBL3741337 | — | — | 1 | 5.03 |
| CHEMBL3741942 | — | — | 1 | - |
| CHEMBL3739799 | — | — | 1 | - |
| CHEMBL3742213 | — | — | 1 | - |
| CHEMBL3739802 | — | — | 1 | - |
| CHEMBL3740172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506450 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL3087706 | — | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL3739795 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL475023 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL3740631 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL3741012 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL3739903 | — | Ki | = | 1760.0 | nM | 5.75 |
| CHEMBL3742158 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL3740141 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL3740619 | — | Ki | = | 3190.0 | nM | 5.50 |
| CHEMBL3741217 | — | Ki | = | 4610.0 | nM | 5.34 |
| CHEMBL3739922 | — | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL3741167 | — | Ki | = | 7490.0 | nM | 5.13 |
| CHEMBL3740992 | — | Ki | = | 8240.0 | nM | 5.08 |
| CHEMBL3739985 | — | Ki | = | 9250.0 | nM | 5.03 |
| CHEMBL3741337 | — | Ki | = | 9280.0 | nM | 5.03 |
| CHEMBL3741942 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3739799 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3742213 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3739802 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3740172 | — | Ki | > | 30000.0 | nM | - |