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Compound Detail

CHEMBL475023

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CCCn1cnc2c(N)ncnc21

Basic Information

ChEMBL ID CHEMBL475023
Phase Preclinical
Structure Type MOL
InChI Key QTULKOMMYIUZQD-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

177.2
MW (Da)
0.82
ALogP
5
HBA
1
HBD
69.6
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H11N5
MW 177.21
Aromatic Rings 2
Heavy Atoms 13
NP-Likeness -1.00

Activity Summary

Ki 6 meas. best 5.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2b
CHEMBL255
Ki 5.77 5.77 1700.0 2
Adenosine receptor A1
CHEMBL226
Ki 5.03 5.03 9400.0 2
Adenosine receptor A2a
CHEMBL251
Ki 5.02 5.02 9600.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A1 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A2a 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A2b 1
19282184 10.1016/j.bmc.2009.02.030 Adenosine receptor A3 1
- 10.1039/C5MD00034C Adenosine receptor A1 1
- 10.1039/C5MD00034C Adenosine receptor A2a 1
- 10.1039/C5MD00034C Adenosine receptor A2b 1
- 10.1039/C5MD00034C Transmembrane domain-containing protein TMIGD3 1

Data from ChEMBL 36 via Core Engine