Assay Detail
Binding
CHEMBL3744150
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of boron-dipyrromethene-cyclopamine from human smoothened receptor expressed in HEK293 cells incubated for 4 hrs by hSMO-BC binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.22 |
| CHEMBL3741651 | — | — | 1 | 7.72 |
| CHEMBL3740447 | — | — | 1 | 7.38 |
| CHEMBL2031084 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3741651 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3740447 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL2031084 | — | IC50 | = | 281.0 | nM | 6.55 |