Assay Detail
Binding
CHEMBL3744201
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Inhibition of agr-mediated quorum sensing in Staphylococcus aureus after 5 hrs by luminescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Accessory gene regulator protein A (CHEMBL1681616) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.90 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3742171 | — | — | 1 | 6.52 |
| CHEMBL1784527 | TURNAGAINOLIDE A | — | 1 | 6.10 |
| CHEMBL3740058 | — | — | 1 | 5.60 |
| CHEMBL3741390 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3742171 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1784527 | TURNAGAINOLIDE A | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3740058 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3741390 | — | IC50 | = | 4400.0 | nM | 5.36 |