Assay Detail
Binding
CHEMBL3744508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HeLa cell membrane after 30 mins by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent 1and 5-HT1Areceptor ligand: an in vitro and computational study
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.28 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741808 | — | — | 1 | 8.61 |
| CHEMBL3739897 | — | — | 1 | 8.52 |
| CHEMBL37883 | — | — | 1 | 8.45 |
| CHEMBL3739932 | — | — | 1 | 8.42 |
| CHEMBL3740374 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741808 | — | Ki | = | 2.455 | nM | 8.61 |
| CHEMBL3739897 | — | Ki | = | 3.02 | nM | 8.52 |
| CHEMBL37883 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL3739932 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL3740374 | — | Ki | = | 40.74 | nM | 7.39 |