Assay Detail
Binding
CHEMBL3744553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from 5HT2C receptor in rat brain cortex
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of amide, sulfonamide and urea benzisoxazole derivatives as potential atypical antipsychotics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.81 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.48 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 6.90 |
| CHEMBL3740256 | — | — | 1 | 6.86 |
| CHEMBL3741292 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 33.1 | nM | 7.48 |
| CHEMBL85 | RISPERIDONE | Ki | = | 125.9 | nM | 6.90 |
| CHEMBL3740256 | — | Ki | = | 136.8 | nM | 6.86 |
| CHEMBL3741292 | — | Ki | = | 998.2 | nM | 6.00 |