Assay Detail
Binding
CHEMBL3744618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [33P]S1P from S1P5 receptor (unknown origin) expressed in HEK cell membranes after 45 to 60 mins by scintillation counting based RLB method
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 7.89 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1990223 | — | — | 1 | 9.00 |
| CHEMBL1966501 | — | — | 1 | 9.00 |
| CHEMBL3741092 | — | — | 1 | 9.00 |
| CHEMBL1973936 | — | — | 1 | 9.00 |
| CHEMBL3739440 | — | — | 1 | 9.00 |
| CHEMBL1986265 | — | — | 1 | 8.70 |
| CHEMBL3741572 | — | — | 1 | 8.70 |
| CHEMBL1998478 | — | — | 1 | 8.70 |
| CHEMBL3740090 | — | — | 1 | 8.52 |
| CHEMBL3740359 | — | — | 1 | 8.52 |
| CHEMBL1971132 | — | — | 1 | 8.40 |
| CHEMBL1968499 | — | — | 1 | 8.40 |
| CHEMBL3740093 | — | — | 1 | 8.30 |
| CHEMBL3741298 | — | — | 1 | 8.30 |
| CHEMBL3741022 | — | — | 1 | 8.30 |
| CHEMBL3739878 | — | — | 1 | 8.30 |
| CHEMBL3741589 | — | — | 1 | 8.22 |
| CHEMBL1987998 | — | — | 1 | 8.22 |
| CHEMBL3742384 | — | — | 1 | 8.15 |
| CHEMBL3742033 | — | — | 1 | 8.10 |
| CHEMBL3741496 | — | — | 1 | 8.05 |
| CHEMBL3740060 | — | — | 1 | 8.05 |
| CHEMBL3739695 | — | — | 1 | 8.05 |
| CHEMBL3741364 | — | — | 1 | 8.05 |
| CHEMBL3742304 | — | — | 1 | 8.00 |
| CHEMBL3742245 | — | — | 1 | 8.00 |
| CHEMBL3739759 | — | — | 1 | 7.80 |
| CHEMBL3741743 | — | — | 1 | 7.80 |
| CHEMBL3742345 | — | — | 1 | 7.64 |
| CHEMBL3739509 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1990223 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3739440 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1973936 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1966501 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3741092 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1986265 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3741572 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1998478 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3740090 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3740359 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1971132 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1968499 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3739878 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3740093 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3741298 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3741022 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3741589 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1987998 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3742384 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3742033 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3741364 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3739695 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3741496 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3740060 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3742304 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3742245 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3739759 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3741743 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3742345 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3739509 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3739964 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3740768 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3741775 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3741459 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3739977 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL3740494 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL3741222 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3740739 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL3741338 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3740188 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL3742100 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL3740219 | — | IC50 | = | 789.0 | nM | 6.10 |
| CHEMBL3742107 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3741414 | — | IC50 | < | 1.0 | nM | - |