Assay Detail
Binding
CHEMBL3744664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Prazosin from alpha-1 adrenergic receptor in rat cerebral cortex after 1 hr by microplate reader based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Arylsulfonamide derivatives of (aryloxy)ethylpiperidines as selective 5-HT7receptor antagonists and their psychotropic properties
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.04 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3739745 | — | — | 1 | 6.41 |
| CHEMBL3740235 | — | — | 1 | 6.23 |
| CHEMBL3742076 | — | — | 1 | 6.20 |
| CHEMBL3739680 | — | — | 1 | 6.15 |
| CHEMBL3740054 | — | — | 1 | 6.01 |
| CHEMBL3740055 | — | — | 1 | 5.70 |
| CHEMBL2159466 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3739745 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL3740235 | — | Ki | = | 589.0 | nM | 6.23 |
| CHEMBL3742076 | — | Ki | = | 629.0 | nM | 6.20 |
| CHEMBL3739680 | — | Ki | = | 712.0 | nM | 6.15 |
| CHEMBL3740054 | — | Ki | = | 979.0 | nM | 6.01 |
| CHEMBL3740055 | — | Ki | = | 2019.0 | nM | 5.70 |
| CHEMBL2159466 | — | Ki | = | 2541.0 | nM | 5.59 |