Assay Detail
Binding
CHEMBL3745445
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin preincubated for 10 mins using Ac-FVR-AMC as substrate by chromogenic assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.43 | 8.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539697 | DABIGATRAN ETEXILATE | 4.0 | 2 | 8.58 |
| CHEMBL3740928 | — | — | 2 | 8.40 |
| CHEMBL3741603 | — | — | 2 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539697 | DABIGATRAN ETEXILATE | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL539697 | DABIGATRAN ETEXILATE | IC50 | = | 2.61 | nM | 8.58 |
| CHEMBL3740928 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3740928 | — | IC50 | = | 3.95 | nM | 8.40 |
| CHEMBL3741603 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3741603 | — | IC50 | = | 4.96 | nM | 8.30 |