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Assay Detail

CHEMBL3745495

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human A431 cells after 72 hrs by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-431
Confidence 1 — Organism
Curated By Autocuration

Target

A-431 (CHEMBL614069)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.
Zhang Y, Tortorella MD, Liao J, Qin X, Chen T, Luo J, Guan J, Talley JJ, Tu Z.
ACS Med Chem Lett (2015) 6 : 1086 -1090
PubMed 26487917 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.62 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL553 ERLOTINIB 4.0 1 6.07
CHEMBL3741490 1 5.90
CHEMBL3739447 1 5.77
CHEMBL3741424 1 5.75
CHEMBL3741026 1 5.66
CHEMBL3740850 1 5.50
CHEMBL3740016 1 5.32
CHEMBL3741640 1 5.30
CHEMBL3742059 1 5.27
CHEMBL3740595 1 -
CHEMBL3741304 1 -
CHEMBL3741399 1 -
CHEMBL3739528 1 -
CHEMBL3739527 1 -
CHEMBL3741768 1 -
CHEMBL3739771 1 -
CHEMBL3740105 1 -
CHEMBL3742139 1 -
CHEMBL3741533 1 -
CHEMBL3740567 1 -
CHEMBL3740951 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL553 ERLOTINIB IC50 = 844.0 nM 6.07
CHEMBL3741490 IC50 = 1270.0 nM 5.90
CHEMBL3739447 IC50 = 1700.0 nM 5.77
CHEMBL3741424 IC50 = 1800.0 nM 5.75
CHEMBL3741026 IC50 = 2200.0 nM 5.66
CHEMBL3740850 IC50 = 3200.0 nM 5.50
CHEMBL3740016 IC50 = 4800.0 nM 5.32
CHEMBL3741640 IC50 = 5000.0 nM 5.30
CHEMBL3742059 IC50 = 5400.0 nM 5.27
CHEMBL3740595 IC50 > 10000.0 nM -
CHEMBL3741304 IC50 > 10000.0 nM -
CHEMBL3741399 IC50 > 10000.0 nM -
CHEMBL3739528 IC50 - -
CHEMBL3739527 IC50 > 10000.0 nM -
CHEMBL3741768 IC50 - -
CHEMBL3739771 IC50 > 10000.0 nM -
CHEMBL3740105 IC50 - -
CHEMBL3742139 IC50 > 10000.0 nM -
CHEMBL3741533 IC50 > 10000.0 nM -
CHEMBL3740567 IC50 > 10000.0 nM -
CHEMBL3740951 IC50 > 10000.0 nM -