Assay Detail
Binding
CHEMBL3748083
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Inhibition of PTP1B (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New Frontiers in Druggability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 8.15 |
| Ki | 2 | 8.63 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1235987 | — | — | 1 | 8.85 |
| CHEMBL541214 | — | — | 1 | 8.40 |
| CHEMBL3746639 | — | — | 1 | 8.15 |
| CHEMBL266753 | — | — | 1 | 7.41 |
| CHEMBL3747361 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1235987 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL541214 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3746639 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL266753 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3747361 | — | IC50 | = | 64.0 | nM | 7.19 |