Assay Detail
Binding
CHEMBL3748433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B using pNPP as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.54 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 6.14 |
| CHEMBL3746974 | — | — | 1 | 5.72 |
| CHEMBL457458 | — | — | 1 | 4.77 |
| CHEMBL3747131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3746974 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL457458 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3747131 | — | IC50 | > | 45000.0 | nM | - |