Assay Detail
Functional
CHEMBL3748699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 expressing JRFL envelope infected in human HeLa67 cells expressing CD4 and CCR5 receptors assessed as inhibition of luciferase activity after 3 days by single cycle pseudotype assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HeLa67 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 9.49 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3745996 | — | — | 1 | 10.70 |
| CHEMBL3745794 | — | — | 1 | 10.70 |
| CHEMBL3747529 | — | — | 1 | 10.52 |
| CHEMBL3747691 | — | — | 1 | 10.22 |
| CHEMBL3746546 | — | — | 1 | 10.10 |
| CHEMBL3747434 | — | — | 1 | 10.05 |
| CHEMBL3301620 | TEMSAVIR | 2.0 | 1 | 10.00 |
| CHEMBL3746461 | — | — | 1 | 10.00 |
| CHEMBL3746003 | — | — | 1 | 9.89 |
| CHEMBL3746570 | — | — | 1 | 9.85 |
| CHEMBL3746041 | — | — | 1 | 9.85 |
| CHEMBL3746085 | — | — | 1 | 9.85 |
| CHEMBL3745982 | — | — | 1 | 9.82 |
| CHEMBL3746511 | — | — | 1 | 9.77 |
| CHEMBL3746649 | — | — | 1 | 9.43 |
| CHEMBL3746625 | — | — | 1 | 9.39 |
| CHEMBL3747712 | — | — | 1 | 9.38 |
| CHEMBL3746318 | — | — | 1 | 9.36 |
| CHEMBL3745999 | — | — | 1 | 9.32 |
| CHEMBL3747208 | — | — | 1 | 9.27 |
| CHEMBL3746727 | — | — | 1 | 9.21 |
| CHEMBL3746732 | — | — | 1 | 9.15 |
| CHEMBL3747339 | — | — | 1 | 8.34 |
| CHEMBL3746785 | — | — | 1 | 8.04 |
| CHEMBL3746748 | — | — | 1 | 7.27 |
| CHEMBL3747197 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3745996 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3745794 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL3747529 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3747691 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL3746546 | — | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL3747434 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL3301620 | TEMSAVIR | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3746461 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL3746003 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3746570 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3746041 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3746085 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3745982 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3746511 | — | EC50 | = | 0.17 | nM | 9.77 |
| CHEMBL3746649 | — | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL3746625 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3747712 | — | EC50 | = | 0.42 | nM | 9.38 |
| CHEMBL3746318 | — | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL3745999 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3747208 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3746727 | — | EC50 | = | 0.62 | nM | 9.21 |
| CHEMBL3746732 | — | EC50 | = | 0.71 | nM | 9.15 |
| CHEMBL3747339 | — | EC50 | = | 4.62 | nM | 8.34 |
| CHEMBL3746785 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3746748 | — | EC50 | = | 53.4 | nM | 7.27 |
| CHEMBL3747197 | — | EC50 | = | 69.2 | nM | 7.16 |