Assay Detail
ADMET
CHEMBL3748829
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Cytotoxicity against mouse BA/F3 cells assessed as cell viability after 72 hrs by MTS assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.81 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747134 | — | — | 1 | 6.26 |
| CHEMBL3746482 | — | — | 1 | 6.25 |
| CHEMBL3747267 | — | — | 1 | 6.24 |
| CHEMBL3735401 | — | — | 1 | 6.23 |
| CHEMBL3736273 | — | — | 1 | 6.12 |
| CHEMBL3746678 | — | — | 1 | 6.08 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.03 |
| CHEMBL3734844 | — | — | 1 | 6.03 |
| CHEMBL3746522 | — | — | 1 | 5.87 |
| CHEMBL3747406 | — | — | 1 | 5.78 |
| CHEMBL3747108 | — | — | 1 | 5.78 |
| CHEMBL3397300 | — | — | 1 | 5.72 |
| CHEMBL3747611 | — | — | 1 | 5.52 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.26 |
| CHEMBL3746960 | — | — | 1 | 5.25 |
| CHEMBL3746665 | — | — | 1 | 5.20 |
| CHEMBL3746395 | — | — | 1 | 5.13 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747134 | — | IC50 | = | 545.0 | nM | 6.26 |
| CHEMBL3746482 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL3747267 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL3735401 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL3736273 | — | IC50 | = | 768.0 | nM | 6.12 |
| CHEMBL3746678 | — | IC50 | = | 831.0 | nM | 6.08 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL3734844 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL3746522 | — | IC50 | = | 1338.0 | nM | 5.87 |
| CHEMBL3747406 | — | IC50 | = | 1651.0 | nM | 5.78 |
| CHEMBL3747108 | — | IC50 | = | 1647.0 | nM | 5.78 |
| CHEMBL3397300 | — | IC50 | = | 1921.0 | nM | 5.72 |
| CHEMBL3747611 | — | IC50 | = | 3014.0 | nM | 5.52 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 5512.0 | nM | 5.26 |
| CHEMBL3746960 | — | IC50 | = | 5646.0 | nM | 5.25 |
| CHEMBL3746665 | — | IC50 | = | 6255.0 | nM | 5.20 |
| CHEMBL3746395 | — | IC50 | = | 7324.0 | nM | 5.13 |
| CHEMBL1738797 | ALECTINIB | IC50 | > | 1000.0 | nM | - |