Assay Detail
Functional
CHEMBL3748835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human DFCI76 cells expressing EML4-ALK L1152R mutant after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DFCI76 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.17 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3735401 | — | — | 1 | 7.72 |
| CHEMBL3397300 | — | — | 1 | 7.52 |
| CHEMBL3746678 | — | — | 1 | 7.52 |
| CHEMBL3746522 | — | — | 1 | 7.35 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.14 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.63 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3735401 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3397300 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3746678 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3746522 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2403108 | CERITINIB | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL601719 | CRIZOTINIB | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL1738797 | ALECTINIB | EC50 | = | 511.0 | nM | 6.29 |