Assay Detail
Functional
CHEMBL3748840
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Antiproliferative activity against human SK-N-SH cells expressing EML4-ALK F1174L mutant after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-SH |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.39 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746678 | — | — | 1 | 6.79 |
| CHEMBL3735401 | — | — | 1 | 6.61 |
| CHEMBL3746522 | — | — | 1 | 6.60 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 6.52 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.43 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 6.06 |
| CHEMBL3397300 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746678 | — | EC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3735401 | — | EC50 | = | 245.0 | nM | 6.61 |
| CHEMBL3746522 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL2403108 | CERITINIB | EC50 | = | 303.0 | nM | 6.52 |
| CHEMBL601719 | CRIZOTINIB | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1738797 | ALECTINIB | EC50 | = | 872.0 | nM | 6.06 |
| CHEMBL3397300 | — | EC50 | = | 1988.0 | nM | 5.70 |