Assay Detail
Functional
CHEMBL3748842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SMS-KCNR cells expressing EML4-ALK R1275Q mutant after 72 hrs by CellTiter-Glo Luminescent Cell Viability Assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SMS-KCNR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.73 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746678 | — | — | 1 | 7.13 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 7.04 |
| CHEMBL3746522 | — | — | 1 | 6.89 |
| CHEMBL3735401 | — | — | 1 | 6.88 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 6.75 |
| CHEMBL3397300 | — | — | 1 | 6.27 |
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746678 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2403108 | CERITINIB | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3746522 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3735401 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL601719 | CRIZOTINIB | EC50 | = | 179.0 | nM | 6.75 |
| CHEMBL3397300 | — | EC50 | = | 535.0 | nM | 6.27 |
| CHEMBL1738797 | ALECTINIB | EC50 | = | 765.0 | nM | 6.12 |