Assay Detail
Functional
CHEMBL3748917
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Antiproliferative activity against human K562/4 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.84 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3745930 | — | — | 1 | 6.82 |
| CHEMBL3747698 | — | — | 1 | 6.82 |
| CHEMBL3747757 | — | — | 1 | 6.68 |
| CHEMBL1652383 | — | — | 1 | 5.37 |
| CHEMBL3746814 | — | — | 1 | 5.18 |
| CHEMBL3746861 | — | — | 1 | 5.01 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.01 |
| CHEMBL3747021 | — | — | 1 | - |
| CHEMBL3746842 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3745930 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3747698 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3747757 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1652383 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL3746814 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL3746861 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL3747021 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3746842 | — | IC50 | > | 100000.0 | nM | - |