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Assay Detail

CHEMBL3749010

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFN-gamma-stimulated nitric oxide production after 17 hrs by Griess assay
ChEMBL ↗
71
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
Mohd Faudzi SM, Leong SW, Abas F, Mohd Aluwi MFF, Rullah K, Lam KW, Ahmad S, Tham CL, Shaari K, Lajis NH
Medchemcomm (2015) 6 : 1069 -1080
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 4.45 4.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3747695 — — 2 4.99
CHEMBL3746137 — — 2 4.83
CHEMBL140 CURCUMIN 3.0 1 4.83
CHEMBL3746233 — — 2 4.79
CHEMBL3745970 — — 2 4.79
CHEMBL3747086 — — 2 4.67
CHEMBL3745808 — — 2 4.66
CHEMBL3746229 — — 2 4.63
CHEMBL3745785 — — 2 4.58
CHEMBL3746187 — — 2 4.57
CHEMBL3747429 — — 2 4.57
CHEMBL3747048 — — 2 4.56
CHEMBL3745756 — — 2 4.41
CHEMBL3746238 — — 2 4.40
CHEMBL3745942 — — 2 4.38
CHEMBL227719 — — 2 4.35
CHEMBL3746800 — — 2 4.34
CHEMBL3745741 — — 2 4.32
CHEMBL3745717 — — 2 4.24
CHEMBL3746324 — — 2 4.23
CHEMBL3746029 — — 2 4.20
CHEMBL3746259 — — 2 4.16
CHEMBL3746989 — — 2 4.15
CHEMBL3745822 — — 2 4.15
CHEMBL3747400 — — 2 4.13
CHEMBL3746151 — — 2 4.11
CHEMBL3746185 — — 1 -
CHEMBL3747137 — — 1 -
CHEMBL3746726 — — 1 -
CHEMBL3747329 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3747695 — IC50 = 10200.0 nM 4.99
CHEMBL3747695 — IC50 = 10232.93 nM 4.99
CHEMBL3746137 — IC50 = 14757.07 nM 4.83
CHEMBL3746137 — IC50 = 14800.0 nM 4.83
CHEMBL140 CURCUMIN IC50 = 14700.0 nM 4.83
CHEMBL3746233 — IC50 = 16400.0 nM 4.79
CHEMBL3745970 — IC50 = 16300.0 nM 4.79
CHEMBL3745970 — IC50 = 16330.52 nM 4.79
CHEMBL3746233 — IC50 = 16443.72 nM 4.78
CHEMBL3747086 — IC50 = 21500.0 nM 4.67
CHEMBL3747086 — IC50 = 21428.91 nM 4.67
CHEMBL3745808 — IC50 = 21800.0 nM 4.66
CHEMBL3745808 — IC50 = 21777.1 nM 4.66
CHEMBL3746229 — IC50 = 23442.29 nM 4.63
CHEMBL3746229 — IC50 = 23500.0 nM 4.63
CHEMBL3745785 — IC50 = 26121.61 nM 4.58
CHEMBL3745785 — IC50 = 26100.0 nM 4.58
CHEMBL3746187 — IC50 = 27110.0 nM 4.57
CHEMBL3747429 — IC50 = 27227.01 nM 4.57
CHEMBL3746187 — IC50 = 27101.92 nM 4.57
CHEMBL3747429 — IC50 = 27200.0 nM 4.57
CHEMBL3747048 — IC50 = 27478.94 nM 4.56
CHEMBL3747048 — IC50 = 27500.0 nM 4.56
CHEMBL3745756 — IC50 = 39264.49 nM 4.41
CHEMBL3745756 — IC50 = 39300.0 nM 4.41
CHEMBL3746238 — IC50 = 39800.0 nM 4.40
CHEMBL3745942 — IC50 = 42000.0 nM 4.38
CHEMBL3745942 — IC50 = 41975.9 nM 4.38
CHEMBL227719 — IC50 = 44565.62 nM 4.35
CHEMBL227719 — IC50 = 44600.0 nM 4.35
CHEMBL3746800 — IC50 = 45814.19 nM 4.34
CHEMBL3746800 — IC50 = 45800.0 nM 4.34
CHEMBL3746238 — IC50 = 45708.82 nM 4.34
CHEMBL3745741 — IC50 = 47863.01 nM 4.32
CHEMBL3745741 — IC50 = 47900.0 nM 4.32
CHEMBL3745717 — IC50 = 57411.65 nM 4.24
CHEMBL3745717 — IC50 = 57400.0 nM 4.24
CHEMBL3746324 — IC50 = 59000.0 nM 4.23
CHEMBL3746324 — IC50 = 58884.37 nM 4.23
CHEMBL3746029 — IC50 = 63826.35 nM 4.20
CHEMBL3746029 — IC50 = 63800.0 nM 4.20
CHEMBL3746259 — IC50 = 68600.0 nM 4.16
CHEMBL3746259 — IC50 = 68548.82 nM 4.16
CHEMBL3746989 — IC50 = 70500.0 nM 4.15
CHEMBL3746989 — IC50 = 70469.31 nM 4.15
CHEMBL3745822 — IC50 = 71200.0 nM 4.15
CHEMBL3745822 — IC50 = 71121.35 nM 4.15
CHEMBL3747400 — IC50 = 73451.39 nM 4.13
CHEMBL3747400 — IC50 = 73600.0 nM 4.13
CHEMBL3746151 — IC50 = 77446.18 nM 4.11