Assay Detail
Binding
CHEMBL3749017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]2-[p(2-carboxyethyl)phenyl-ethylamino]-5'-N-ethylcarboxamido-adenosine from human adenosine A2A receptor stably expressed in HEK293 cell membrane by radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.76 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747209 | — | — | 1 | 5.96 |
| CHEMBL3746487 | — | — | 1 | 5.56 |
| CHEMBL3745851 | — | — | 1 | - |
| CHEMBL3746886 | — | — | 1 | - |
| CHEMBL3746784 | — | — | 1 | - |
| CHEMBL3746890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747209 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL3746487 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL3745851 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3746886 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3746784 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3746890 | — | Ki | > | 10000.0 | nM | - |