Assay Detail
Binding
CHEMBL3749019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from human adenosine A3 receptor stably expressed in CHO cell membrane by radioligand binding assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transmembrane domain-containing protein TMIGD3 (CHEMBL3712907) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.84 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747303 | — | — | 1 | 9.27 |
| CHEMBL3746778 | — | — | 1 | 9.24 |
| CHEMBL3746260 | — | — | 1 | 9.16 |
| CHEMBL3612943 | — | — | 1 | 9.14 |
| CHEMBL3747209 | — | — | 1 | 9.07 |
| CHEMBL3747005 | — | — | 1 | 9.07 |
| CHEMBL3746512 | — | — | 1 | 9.04 |
| CHEMBL3746774 | — | — | 1 | 9.02 |
| CHEMBL3747276 | — | — | 1 | 9.02 |
| CHEMBL3746358 | — | — | 1 | 9.02 |
| CHEMBL3746487 | — | — | 1 | 8.97 |
| CHEMBL3747457 | — | — | 1 | 8.97 |
| CHEMBL3612944 | — | — | 1 | 8.91 |
| CHEMBL3747461 | — | — | 1 | 8.91 |
| CHEMBL3745837 | — | — | 1 | 8.90 |
| CHEMBL3746890 | — | — | 1 | 8.81 |
| CHEMBL3747756 | — | — | 1 | 8.73 |
| CHEMBL3745807 | — | — | 1 | 8.67 |
| CHEMBL3747321 | — | — | 1 | 8.66 |
| CHEMBL3747670 | — | — | 1 | 8.46 |
| CHEMBL3746784 | — | — | 1 | 8.18 |
| CHEMBL3745851 | — | — | 1 | 8.15 |
| CHEMBL3746886 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747303 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL3746778 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL3746260 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL3612943 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL3747209 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL3747005 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL3746512 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL3746774 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL3747276 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL3746358 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL3746487 | — | Ki | = | 1.08 | nM | 8.97 |
| CHEMBL3747457 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL3612944 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL3747461 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL3745837 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL3746890 | — | Ki | = | 1.53 | nM | 8.81 |
| CHEMBL3747756 | — | Ki | = | 1.84 | nM | 8.73 |
| CHEMBL3745807 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL3747321 | — | Ki | = | 2.21 | nM | 8.66 |
| CHEMBL3747670 | — | Ki | = | 3.48 | nM | 8.46 |
| CHEMBL3746784 | — | Ki | = | 6.66 | nM | 8.18 |
| CHEMBL3745851 | — | Ki | = | 7.05 | nM | 8.15 |
| CHEMBL3746886 | — | Ki | = | 9.02 | nM | 8.04 |