Assay Detail
Binding
CHEMBL3749020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse adenosine A3 receptor stably expressed in CHO cell membrane by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.64 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746886 | — | — | 1 | 8.19 |
| CHEMBL3612944 | — | — | 1 | 8.02 |
| CHEMBL3745851 | — | — | 1 | 7.85 |
| CHEMBL3747670 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746886 | — | Ki | = | 6.53 | nM | 8.19 |
| CHEMBL3612944 | — | Ki | = | 9.64 | nM | 8.02 |
| CHEMBL3745851 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL3747670 | — | Ki | = | 334.0 | nM | 6.48 |