Assay Detail
Binding
CHEMBL3749446
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Binding affinity to vitamin D3 receptor (unknown origin) after 4 hrs using fluormone VDR red by polar screen VDR competitor assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel nonsecosteroidal VDR ligands with phenyl-pyrrolyl pentane skeleton for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.33 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | 4.0 | 1 | 8.95 |
| CHEMBL3747730 | — | — | 1 | 7.15 |
| CHEMBL3746465 | — | — | 1 | 6.71 |
| CHEMBL3747184 | — | — | 1 | 6.71 |
| CHEMBL3747703 | — | — | 1 | 6.41 |
| CHEMBL3747394 | — | — | 1 | 6.25 |
| CHEMBL3747341 | — | — | 1 | 6.06 |
| CHEMBL3747314 | — | — | 1 | 6.00 |
| CHEMBL3746013 | — | — | 1 | 5.92 |
| CHEMBL3747293 | — | — | 1 | 5.45 |
| CHEMBL3747642 | — | — | 1 | 5.28 |
| CHEMBL3747395 | — | — | 1 | 5.03 |
| CHEMBL3747218 | — | — | 1 | - |
| CHEMBL3746404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL846 | CALCITRIOL | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL3747730 | — | IC50 | = | 71.06 | nM | 7.15 |
| CHEMBL3746465 | — | IC50 | = | 196.6 | nM | 6.71 |
| CHEMBL3747184 | — | IC50 | = | 194.3 | nM | 6.71 |
| CHEMBL3747703 | — | IC50 | = | 389.3 | nM | 6.41 |
| CHEMBL3747394 | — | IC50 | = | 563.6 | nM | 6.25 |
| CHEMBL3747341 | — | IC50 | = | 863.0 | nM | 6.06 |
| CHEMBL3747314 | — | IC50 | = | 1007.0 | nM | 6.00 |
| CHEMBL3746013 | — | IC50 | = | 1189.0 | nM | 5.92 |
| CHEMBL3747293 | — | IC50 | = | 3521.0 | nM | 5.45 |
| CHEMBL3747642 | — | IC50 | = | 5235.0 | nM | 5.28 |
| CHEMBL3747395 | — | IC50 | = | 9245.0 | nM | 5.03 |
| CHEMBL3747218 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3746404 | — | IC50 | > | 10000.0 | nM | - |