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Assay Detail

CHEMBL3749681

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ADMET
Antiproliferative activity against mouse NIH/3T3 cells after 48 hrs by cell impedance based study
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type NIH3T3
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558)
Type ADMET

Publication

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD(+)/NADH Ratio and SIRT1.
Tikhomirov AS, Shchekotikhin AE, Lee YH, Chen YA, Yeh CA, Tatarskiy VV, Dezhenkova LG, Glazunova VA, Balzarini J, Shtil AA, Preobrazhenskaya MN, Chueh PJ.
J Med Chem (2015) 58 : 9522 -9534
PubMed 26633734 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.64 6.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3747698 1 6.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3747698 IC50 = 230.0 nM 6.64