Assay Detail
Binding
CHEMBL3749752
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Inhibition of diphenolase activity of mushroom tyrosinase using L-DOPA as substrate preincubated with substrate for 10 mins followed by protein addition measured after 15 mins by spectrophotometric analysis
19
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.44 | 6.30 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747057 | — | — | 2 | 6.30 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.58 |
| CHEMBL3745963 | — | — | 1 | - |
| CHEMBL3745949 | — | — | 1 | - |
| CHEMBL3746021 | — | — | 1 | - |
| CHEMBL3747631 | — | — | 1 | - |
| CHEMBL3747601 | — | — | 1 | - |
| CHEMBL3746555 | — | — | 1 | - |
| CHEMBL3746307 | — | — | 1 | - |
| CHEMBL3745965 | — | — | 1 | - |
| CHEMBL3747773 | — | — | 1 | - |
| CHEMBL3746877 | — | — | 1 | - |
| CHEMBL3746218 | — | — | 2 | - |
| CHEMBL3746757 | — | — | 2 | - |
| CHEMBL3745886 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747057 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL3745949 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3746021 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3747631 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3747601 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3746555 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3746307 | — | IC50 | = | 146400.0 | nM | - |
| CHEMBL3745965 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3747773 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3745963 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3746218 | — | Inhibition | - | % | - | |
| CHEMBL3747057 | — | Inhibition | - | % | - | |
| CHEMBL3746757 | — | Inhibition | - | % | - | |
| CHEMBL3745886 | — | Inhibition | - | % | - | |
| CHEMBL3746218 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL3746757 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3745886 | — | IC50 | = | 128200.0 | nM | - |
| CHEMBL3746877 | — | IC50 | > | 200000.0 | nM | - |