Assay Detail
Binding
CHEMBL3750502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.50 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.82 |
| CHEMBL164 | MYRICETIN | — | 1 | 4.82 |
| CHEMBL28626 | MORIN | — | 1 | 4.52 |
| CHEMBL66 | (+)-TAXIFOLIN | — | 1 | 4.48 |
| CHEMBL503168 | DATISCETIN | — | 1 | 4.26 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.12 |
| CHEMBL309490 | GALANGIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL164 | MYRICETIN | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL28626 | MORIN | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL66 | (+)-TAXIFOLIN | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL503168 | DATISCETIN | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL309490 | GALANGIN | IC50 | > | 500000.0 | nM | - |