Assay Detail
Binding
CHEMBL3750679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cytochrome P450 11B2, mitochondrial (CHEMBL3237) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746175 | — | — | 1 | 5.70 |
| CHEMBL3746125 | — | — | 1 | 5.41 |
| CHEMBL3747269 | — | — | 1 | 5.10 |
| CHEMBL3746868 | — | — | 1 | 4.96 |
| CHEMBL3747562 | — | — | 1 | 4.56 |
| CHEMBL3747069 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746175 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3746125 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3747269 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3746868 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3747562 | — | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL3747069 | — | IC50 | = | 53100.0 | nM | 4.28 |