Assay Detail
Functional
CHEMBL3750738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Suppression of PGE2 production in LPS-induced mouse RAW264.7 cells after 24 hrs by enzyme immunoassay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.93 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3746729 | — | — | 1 | 8.35 |
| CHEMBL7162 | NS-398 | — | 1 | 8.15 |
| CHEMBL3746332 | — | — | 1 | 7.77 |
| CHEMBL3746498 | — | — | 1 | 7.69 |
| CHEMBL3746507 | — | — | 1 | 7.54 |
| CHEMBL3746705 | — | — | 1 | 7.49 |
| CHEMBL3746542 | — | — | 1 | 7.47 |
| CHEMBL3747473 | — | — | 1 | 7.30 |
| CHEMBL3747438 | — | — | 1 | 7.25 |
| CHEMBL3747728 | — | — | 1 | 7.09 |
| CHEMBL3746060 | — | — | 1 | 7.03 |
| CHEMBL3747000 | — | — | 1 | 6.87 |
| CHEMBL3746276 | — | — | 1 | 6.79 |
| CHEMBL3747171 | — | — | 1 | 6.78 |
| CHEMBL3747031 | — | — | 1 | 6.75 |
| CHEMBL3746001 | — | — | 1 | 6.31 |
| CHEMBL3746349 | — | — | 1 | 6.23 |
| CHEMBL3746644 | — | — | 1 | 6.00 |
| CHEMBL3746834 | — | — | 1 | 5.99 |
| CHEMBL3746543 | — | — | 1 | 5.35 |
| CHEMBL3746195 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3746729 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL7162 | NS-398 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3746332 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL3746498 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL3746507 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL3746705 | — | IC50 | = | 32.6 | nM | 7.49 |
| CHEMBL3746542 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL3747473 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3747438 | — | IC50 | = | 56.9 | nM | 7.25 |
| CHEMBL3747728 | — | IC50 | = | 81.5 | nM | 7.09 |
| CHEMBL3746060 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3747000 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL3746276 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL3747171 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3747031 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3746001 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3746349 | — | IC50 | = | 584.0 | nM | 6.23 |
| CHEMBL3746644 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3746834 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3746543 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL3746195 | — | IC50 | = | 5720.0 | nM | 5.24 |