Assay Detail
Functional
CHEMBL3750827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Decrease in ACTH-stimulated plasma aldosterone level in po dosed chair-trained chronically cannulated cynomolgus monkey model compound administered followed by ACTH challenge for 3 hrs measured after 24 hrs by LC/MS/MS analysis
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 1 | - | - |
| ED50 | 1 | - | - |
| EC50 | 1 | 8.07 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747562 | — | — | 3 | 8.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747562 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3747562 | — | Activity | - | — | - | |
| CHEMBL3747562 | — | ED50 | = | 0.061 | mg.kg-1 | - |