Assay Detail
Functional
CHEMBL3751505
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ent-Abietane-type diterpenoids from the roots of Euphorbia ebracteolata with their inhibitory activities on LPS-induced NO production in RAW 264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.12 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747302 | — | — | 1 | 6.16 |
| CHEMBL404387 | JOLKINOLIDE B | — | 1 | 6.06 |
| CHEMBL3747221 | — | — | 1 | 5.71 |
| CHEMBL3746044 | — | — | 1 | 5.35 |
| CHEMBL3746967 | — | — | 1 | 5.23 |
| CHEMBL3746430 | — | — | 1 | 5.16 |
| CHEMBL3746737 | — | — | 1 | 4.85 |
| CHEMBL3745928 | — | — | 1 | 4.81 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 4.78 |
| CHEMBL1982058 | — | — | 1 | 4.60 |
| CHEMBL3746722 | — | — | 1 | 4.48 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747302 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL404387 | JOLKINOLIDE B | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3747221 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL3746044 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL3746967 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL3746430 | — | IC50 | = | 6980.0 | nM | 5.16 |
| CHEMBL3746737 | — | IC50 | = | 14250.0 | nM | 4.85 |
| CHEMBL3745928 | — | IC50 | = | 15450.0 | nM | 4.81 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 16670.0 | nM | 4.78 |
| CHEMBL1982058 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3746722 | — | IC50 | = | 33060.0 | nM | 4.48 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 54230.0 | nM | 4.27 |