Assay Detail
Functional
CHEMBL3751572
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Antiviral activity against HIV-1 SF162 infected in TZM-bl cells after 2 days by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 6.10 |
| CHEMBL599936 | — | — | 1 | 5.85 |
| CHEMBL216826 | — | — | 1 | 5.75 |
| CHEMBL3746755 | — | — | 1 | 5.33 |
| CHEMBL475086 | RUBROFUSARIN | — | 1 | 4.25 |
| CHEMBL3745791 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1380 | ABACAVIR | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL599936 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL216826 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3746755 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL475086 | RUBROFUSARIN | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL3745791 | — | IC50 | = | 83200.0 | nM | 4.08 |