Assay Detail
Functional
CHEMBL3751578
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Antiviral activity against HIV1 3B persistently infected in HUT78 cells assessed as reduction of p24 production after 43 hrs by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | HuT78 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.08 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.58 |
| CHEMBL418037 | — | — | 1 | 5.58 |
| CHEMBL3746006 | — | — | 1 | 5.08 |
| CHEMBL3747547 | — | — | 1 | 4.85 |
| CHEMBL3747739 | — | — | 1 | 4.81 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 4.54 |
| CHEMBL3747070 | — | — | 1 | 4.13 |
| CHEMBL3746975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL418037 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL3746006 | — | EC50 | = | 8250.0 | nM | 5.08 |
| CHEMBL3747547 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3747739 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL163 | RITONAVIR | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3747070 | — | EC50 | = | 73200.0 | nM | 4.13 |
| CHEMBL3746975 | — | EC50 | > | 7500.0 | nM | - |