Assay Detail
Functional
CHEMBL3751585
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against NRTI/NNRTI-resistant HIV1 L6 harboring reverse transcriptase V75I/F77L/K103N/F116Y/Q151M/M184V mutant infected in human MT4 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.08 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747547 | — | — | 1 | 5.46 |
| CHEMBL3747739 | — | — | 1 | 5.18 |
| CHEMBL3747070 | — | — | 1 | 4.59 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747547 | — | EC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL3747739 | — | EC50 | = | 6590.0 | nM | 5.18 |
| CHEMBL3747070 | — | EC50 | = | 25920.0 | nM | 4.59 |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 7480.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 15000.0 | nM | - |