Assay Detail
Functional
CHEMBL3751586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ritonavir-resistant HIV1 B12 harboring reverse transcriptase L10I/I15V/I54V/L63P/V82A/I85V mutant infected in human MT4 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.12 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.89 |
| CHEMBL3747547 | — | — | 1 | 5.19 |
| CHEMBL3747739 | — | — | 1 | 4.84 |
| CHEMBL3747070 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3747547 | — | EC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL3747739 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3747070 | — | EC50 | = | 27710.0 | nM | 4.56 |