Assay Detail
Functional
CHEMBL3751588
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Antiviral activity against nevirapine-resistant SIV mac251 infected in human MT4 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Simian immunodeficiency virus - mac251 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of DiselenoBisBenzamides (DISeBAs) as Nucleocapsid Protein 7 (NCp7) Inhibitors with anti-HIV Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.76 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.85 |
| CHEMBL3747739 | — | — | 1 | 5.77 |
| CHEMBL3747547 | — | — | 1 | 5.66 |
| CHEMBL3747070 | — | — | 1 | 4.76 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163 | RITONAVIR | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3747739 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3747547 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3747070 | — | EC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 15000.0 | nM | - |