Assay Detail
Functional
CHEMBL3755093
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Antagonist activity at recombinant human H3 receptor expressed on CHO-K1 cells assessed as cAMP level by luciferase gene reporter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.11 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753475 | — | — | 1 | 8.32 |
| CHEMBL3753901 | — | — | 1 | 7.84 |
| CHEMBL3752655 | — | — | 1 | 6.56 |
| CHEMBL3753093 | — | — | 1 | 6.49 |
| CHEMBL3753703 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753475 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3753901 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL3752655 | — | IC50 | = | 273.9 | nM | 6.56 |
| CHEMBL3753093 | — | IC50 | = | 323.8 | nM | 6.49 |
| CHEMBL3753703 | — | IC50 | = | 458.7 | nM | 6.34 |