Assay Detail
Functional
CHEMBL3755457
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.18 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.49 |
| CHEMBL3753643 | — | — | 1 | 7.70 |
| CHEMBL3753517 | — | — | 1 | 6.34 |
| CHEMBL3752157 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3753643 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3753517 | — | EC50 | = | 456.0 | nM | 6.34 |
| CHEMBL3752157 | — | EC50 | = | 680.0 | nM | 6.17 |