Assay Detail
Binding
CHEMBL3755646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His-tagged SIRT2 (13 to 319 residues) using human p53 derived peptides as substrate incubated for 45 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a potent and highly fluorescent sirtuin inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.71 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224864 | — | — | 1 | 5.10 |
| CHEMBL3754317 | — | — | 1 | 5.05 |
| CHEMBL3752617 | — | — | 1 | 4.87 |
| CHEMBL595354 | — | — | 1 | 4.57 |
| CHEMBL420311 | — | — | 1 | 4.36 |
| CHEMBL3752305 | — | — | 1 | 4.28 |
| CHEMBL3752528 | — | — | 1 | - |
| CHEMBL3751949 | — | — | 1 | - |
| CHEMBL3752548 | — | — | 1 | - |
| CHEMBL3754315 | — | — | 1 | - |
| CHEMBL3751867 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224864 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3754317 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3752617 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL595354 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL420311 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL3752305 | — | IC50 | = | 52910.0 | nM | 4.28 |
| CHEMBL3752528 | — | IC50 | - | — | - | |
| CHEMBL3751949 | — | IC50 | - | — | - | |
| CHEMBL3752548 | — | IC50 | - | — | - | |
| CHEMBL3754315 | — | IC50 | - | — | - | |
| CHEMBL3751867 | — | IC50 | - | — | - |