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Assay Detail

CHEMBL3755949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometric analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.
Wang Y, Yuk HJ, Kim JY, Kim DW, Song YH, Tan XF, Curtis-Long MJ, Park KH.
Bioorg Med Chem Lett (2016) 26 : 318 -321
PubMed 26704263 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.97 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2442947 1 5.62
CHEMBL459129 AURICULASIN 1 5.44
CHEMBL3754629 1 5.19
CHEMBL494252 1 5.03
CHEMBL169 URSOLIC ACID 2.0 1 4.81
CHEMBL2442946 FLEMINGSIN 1 4.76
CHEMBL3754570 1 4.70
CHEMBL238188 OSAJIN 1 4.63
CHEMBL3753821 1 4.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2442947 IC50 = 2400.0 nM 5.62
CHEMBL459129 AURICULASIN IC50 = 3600.0 nM 5.44
CHEMBL3754629 IC50 = 6500.0 nM 5.19
CHEMBL494252 IC50 = 9300.0 nM 5.03
CHEMBL169 URSOLIC ACID IC50 = 15500.0 nM 4.81
CHEMBL2442946 FLEMINGSIN IC50 = 17400.0 nM 4.76
CHEMBL3754570 IC50 = 20200.0 nM 4.70
CHEMBL238188 OSAJIN IC50 = 23600.0 nM 4.63
CHEMBL3753821 IC50 = 29400.0 nM 4.53