Assay Detail
Binding
CHEMBL3755950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometry based Lineweaver-Burk plot
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel chromenedione derivatives displaying inhibition of protein tyrosine phosphatase 1B (PTP1B) from Flemingia philippinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.04 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2442947 | — | — | 1 | 5.60 |
| CHEMBL459129 | AURICULASIN | — | 1 | 5.36 |
| CHEMBL494252 | — | — | 1 | 5.02 |
| CHEMBL2442946 | FLEMINGSIN | — | 1 | 4.72 |
| CHEMBL238188 | OSAJIN | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2442947 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL459129 | AURICULASIN | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL494252 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL2442946 | FLEMINGSIN | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL238188 | OSAJIN | Ki | = | 29900.0 | nM | 4.52 |