Assay Detail
Binding
CHEMBL3756033
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Inhibition of recombinant human MMP9 after 2 hrs using FS-6 as substrate by fluorometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.25 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3754094 | — | — | 1 | 8.28 |
| CHEMBL179288 | — | — | 1 | 8.17 |
| CHEMBL1090284 | — | — | 1 | 8.14 |
| CHEMBL573714 | — | — | 1 | 7.01 |
| CHEMBL3752513 | — | — | 1 | 5.70 |
| CHEMBL3754100 | — | — | 1 | 5.21 |
| CHEMBL3752374 | — | — | 1 | 5.09 |
| CHEMBL3753984 | — | — | 1 | 4.58 |
| CHEMBL228230 | — | — | 1 | 4.09 |
| CHEMBL3751971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3754094 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL179288 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1090284 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL573714 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3752513 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3754100 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3752374 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3753984 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL228230 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL3751971 | — | IC50 | > | 10000.0 | nM | - |