Assay Detail
Binding
CHEMBL3756035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Bacillus thermoproteolyticus pseudolysin pretreated with compound for 15 mins followed by the addition of Abz-Ala-Gly-leu-Ala-p-nitrobenzalamide as substrate by spectrofluorometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Elastase (CHEMBL1075146) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.86 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228230 | — | — | 1 | 5.96 |
| CHEMBL3754100 | — | — | 1 | 5.48 |
| CHEMBL3751971 | — | — | 1 | 5.16 |
| CHEMBL3752374 | — | — | 1 | 4.80 |
| CHEMBL573714 | — | — | 1 | 4.77 |
| CHEMBL3754094 | — | — | 1 | 4.54 |
| CHEMBL3753984 | — | — | 1 | 4.52 |
| CHEMBL3752513 | — | — | 1 | 4.29 |
| CHEMBL179288 | — | — | 1 | 4.24 |
| CHEMBL1090284 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228230 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3754100 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3751971 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3752374 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL573714 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3754094 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3753984 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3752513 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL179288 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL1090284 | — | IC50 | = | 103000.0 | nM | - |