Assay Detail
Binding
CHEMBL3756036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pseudomonas aeruginosa pseudolysin pretreated with compound for 1 hr followed by the addition of 1.73 uM bradykinin like substrate by spectrofluorometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Elastase (CHEMBL1075146) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.66 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228230 | — | — | 1 | 5.72 |
| CHEMBL573714 | — | — | 1 | 4.54 |
| CHEMBL3754100 | — | — | 1 | 4.51 |
| CHEMBL3751971 | — | — | 1 | 4.42 |
| CHEMBL3753984 | — | — | 1 | 4.10 |
| CHEMBL3752513 | — | — | 1 | - |
| CHEMBL3752374 | — | — | 1 | - |
| CHEMBL3754094 | — | — | 1 | - |
| CHEMBL1090284 | — | — | 1 | - |
| CHEMBL179288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228230 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL573714 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3754100 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3751971 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3753984 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3752513 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL3752374 | — | IC50 | - | — | - | |
| CHEMBL3754094 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL1090284 | — | IC50 | - | — | - | |
| CHEMBL179288 | — | IC50 | = | 798000.0 | nM | - |