Assay Detail
Binding
CHEMBL3756038
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Inhibition of Bacillus thermoproteolyticus thermolysin pretreated with compound for 1 hr followed by the addition of 3.33 uM bradykinin like substrate by spectrofluorometry assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus thermoproteolyticus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.69 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228230 | — | — | 1 | 5.02 |
| CHEMBL3754100 | — | — | 1 | 4.54 |
| CHEMBL3753984 | — | — | 1 | 4.52 |
| CHEMBL3752513 | — | — | 1 | - |
| CHEMBL3752374 | — | — | 1 | - |
| CHEMBL3751971 | — | — | 1 | - |
| CHEMBL573714 | — | — | 1 | - |
| CHEMBL3754094 | — | — | 1 | - |
| CHEMBL1090284 | — | — | 1 | - |
| CHEMBL179288 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228230 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3754100 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3753984 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3752513 | — | IC50 | = | 438000.0 | nM | - |
| CHEMBL3752374 | — | IC50 | - | — | - | |
| CHEMBL3751971 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL573714 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL3754094 | — | IC50 | = | 608000.0 | nM | - |
| CHEMBL1090284 | — | IC50 | - | — | - | |
| CHEMBL179288 | — | IC50 | = | 800000.0 | nM | - |