Assay Detail
Functional
CHEMBL3756041
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Antiproliferative activity against human LoVo/DX cells assessed as reduction in cell viability after 72 hrs by SRB assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo/DX |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.95 | 5.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752002 | — | — | 1 | 5.63 |
| CHEMBL3752304 | — | — | 1 | 5.61 |
| CHEMBL3754699 | — | — | 1 | 5.46 |
| CHEMBL81201 | — | — | 1 | 5.41 |
| CHEMBL3752507 | — | — | 1 | 5.38 |
| CHEMBL3752412 | — | — | 1 | 5.32 |
| CHEMBL3752524 | — | — | 1 | 5.18 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.14 |
| CHEMBL3752846 | — | — | 1 | 5.11 |
| CHEMBL3752941 | — | — | 1 | 5.10 |
| CHEMBL3752573 | — | — | 1 | 5.02 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | — | 1 | 5.01 |
| CHEMBL2104676 | BITOSCANATE | 2.0 | 1 | 4.94 |
| CHEMBL3754062 | — | — | 1 | 4.89 |
| CHEMBL3754532 | — | — | 1 | 4.85 |
| CHEMBL3753774 | — | — | 1 | 4.78 |
| CHEMBL3752558 | — | — | 1 | 4.71 |
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | — | 1 | 4.70 |
| CHEMBL3754172 | — | — | 1 | 4.65 |
| CHEMBL3752230 | — | — | 1 | 4.37 |
| CHEMBL3753220 | — | — | 1 | 4.33 |
| CHEMBL3754345 | — | — | 1 | 4.25 |
| CHEMBL1814589 | 1-ISOTHIOCYANATOPENTANE | — | 1 | 4.12 |
| CHEMBL3752979 | — | — | 1 | - |
| CHEMBL3753982 | — | — | 1 | - |
| CHEMBL1814588 | BUTYL ISOTHIOCYANATE | — | 1 | - |
| CHEMBL2251726 | PROPYL ISOTHIOCYANATE | — | 1 | - |
| CHEMBL3753294 | — | — | 1 | - |
| CHEMBL3754758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752002 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL3752304 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL3754699 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL81201 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3752507 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3752412 | — | IC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL3752524 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3752846 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL3752941 | — | IC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL3752573 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL2104676 | BITOSCANATE | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3754062 | — | IC50 | = | 12850.0 | nM | 4.89 |
| CHEMBL3754532 | — | IC50 | = | 14180.0 | nM | 4.85 |
| CHEMBL3753774 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3752558 | — | IC50 | = | 19380.0 | nM | 4.71 |
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3754172 | — | IC50 | = | 22350.0 | nM | 4.65 |
| CHEMBL3752230 | — | IC50 | = | 42800.0 | nM | 4.37 |
| CHEMBL3753220 | — | IC50 | = | 47320.0 | nM | 4.33 |
| CHEMBL3754345 | — | IC50 | = | 55720.0 | nM | 4.25 |
| CHEMBL1814589 | 1-ISOTHIOCYANATOPENTANE | IC50 | = | 75200.0 | nM | 4.12 |
| CHEMBL3752979 | — | IC50 | = | 473410.0 | nM | - |
| CHEMBL3753982 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL1814588 | BUTYL ISOTHIOCYANATE | IC50 | = | 265000.0 | nM | - |
| CHEMBL2251726 | PROPYL ISOTHIOCYANATE | IC50 | = | 177000.0 | nM | - |
| CHEMBL3753294 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3754758 | — | IC50 | = | 134000.0 | nM | - |