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Assay Detail

CHEMBL3756444

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PC3 cells after 3 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Autocuration

Publication

Oxidative burst inhibition, cytotoxicity and antibacterial acriquinoline alkaloids from Citrus reticulate (Blanco).
Fomani M, Ngeufa Happi E, Nouga Bisoue A, Ndom JC, Kamdem Waffo AF, Sewald N, Wansi JD.
Bioorg Med Chem Lett (2016) 26 : 306 -309
PubMed 26711890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 4.39 6.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 6.05
CHEMBL1928409 SUBEROSIN 1 4.29
CHEMBL325864 SCOPARONE 1 4.26
CHEMBL465808 ATALANTOFLAVONE 1 4.25
CHEMBL3753940 1 4.22
CHEMBL3754791 1 4.16
CHEMBL3752565 1 4.15
CHEMBL3752540 1 4.12
CHEMBL140796 ISOPIMPINELLIN 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 900.0 nM 6.05
CHEMBL1928409 SUBEROSIN IC50 = 51300.0 nM 4.29
CHEMBL325864 SCOPARONE IC50 = 54400.0 nM 4.26
CHEMBL465808 ATALANTOFLAVONE IC50 = 55600.0 nM 4.25
CHEMBL3753940 IC50 = 60100.0 nM 4.22
CHEMBL3754791 IC50 = 70000.0 nM 4.16
CHEMBL3752565 IC50 = 71500.0 nM 4.15
CHEMBL3752540 IC50 = 75800.0 nM 4.12
CHEMBL140796 ISOPIMPINELLIN IC50 = 99800.0 nM 4.00