Assay Detail
Binding
CHEMBL3756567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant TNIK (unknown origin) using LRRKtide as substrate after 1 hr in presence of 3 uM ATP
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
TRAF2 and NCK-interacting protein kinase (CHEMBL4527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of TRAF-2 and NCK-interacting kinase (TNIK) inhibitors by ligand-based virtual screening methods
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.56 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 8.70 |
| CHEMBL3754324 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522892 | DOVITINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3754324 | — | IC50 | = | 394.0 | nM | 6.41 |