Assay Detail
Binding
CHEMBL3757063
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Inhibition of PCAF bromodomain (719 to 832 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells by NMR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragments in bromodomain drug discovery
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.55 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL609728 | — | — | 1 | 5.80 |
| CHEMBL1234797 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL609728 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1234797 | — | IC50 | = | 5000.0 | nM | 5.30 |