Assay Detail
Binding
CHEMBL3757071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of biotinylated H4(1 to 24 amino acid residues)-K5/8/12/16Ac from human N-terminal His6-tagged BRD4 bromodomain-1 expressed in Escherichia coli BL21(DE3) cells by alpha screen assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fragments in bromodomain drug discovery
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.60 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | — | 1 | 5.60 |
| CHEMBL14212 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL14212 | — | IC50 | = | 2500.0 | nM | 5.60 |