Assay Detail
Binding
CHEMBL3757147
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Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydroxylated chalcones with dual properties: Xanthine oxidase inhibitors and radical scavengers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.03 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222557 | — | — | 1 | 5.92 |
| CHEMBL128000 | BUTEIN | — | 1 | 5.89 |
| CHEMBL225618 | — | — | 1 | 5.52 |
| CHEMBL341135 | — | — | 1 | 5.37 |
| CHEMBL126669 | — | — | 1 | 5.28 |
| CHEMBL3754082 | — | — | 1 | 5.26 |
| CHEMBL1966973 | — | — | 1 | 5.19 |
| CHEMBL3754006 | — | — | 1 | 5.07 |
| CHEMBL125800 | — | — | 1 | 4.77 |
| CHEMBL3754732 | — | — | 1 | 4.75 |
| CHEMBL1083821 | — | — | 1 | 4.57 |
| CHEMBL3752751 | — | — | 1 | 4.46 |
| CHEMBL129510 | — | — | 1 | 4.28 |
| CHEMBL3753041 | — | — | 1 | 4.03 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL2282149 | — | — | 1 | - |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL147067 | — | — | 1 | - |
| CHEMBL7747 | 4-HYDROXYCHALCONE | — | 1 | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222557 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL128000 | BUTEIN | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL225618 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL341135 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL126669 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3754082 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1966973 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3754006 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL125800 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3754732 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1083821 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3752751 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL129510 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL3753041 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | - | — | - | |
| CHEMBL2282149 | — | IC50 | - | — | - | |
| CHEMBL276473 | 4'-HYDROXYCHALCONE | IC50 | - | — | - | |
| CHEMBL147067 | — | IC50 | - | — | - | |
| CHEMBL7747 | 4-HYDROXYCHALCONE | IC50 | = | 290000.0 | nM | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | IC50 | - | — | - |